Increased MMPs Expression and Decreased Contraction in the Rat Myometrium 3 during Pregnancy and in Response to Prolonged Stretch and Sex Hormones
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چکیده
1 1 2 Increased MMPs Expression and Decreased Contraction in the Rat Myometrium 3 during Pregnancy and in Response to Prolonged Stretch and Sex Hormones 4 5 6 Zongzhi Yin, Alaa A. Sada, Ossama M. Reslan, Neha Narula, 7 Raouf A. Khalil 8 9 10 Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, 11 Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA 12 13 14 Running Title: MMPs Expression and Myometrium Relaxation during Pregnancy 15 16 17 Correspondence and Reprints: 18 Raouf A Khalil, MD, PhD 19 Harvard Medical School 20 Brigham and Women’s Hospital 21 Division of Vascular Surgery 22 75 Francis Street 23 Boston, MA 02115 24 Tel : (617) 525-8530 25 Fax : (617) 264-5124 26 E-mail : [email protected] 27 28 29 List of Abbreviations: E2, 17β-estradiol; MMP, matrix metalloproteinase; P4, progesterone 30 31 32 Articles in PresS. Am J Physiol Endocrinol Metab (April 10, 2012). doi:10.1152/ajpendo.00553.2011
منابع مشابه
Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones.
Normal pregnancy is associated with uterine relaxation to accommodate the stretch imposed by the growing fetus; however, the mechanisms underlying the relationship between pregnancy-associated uterine stretch and uterine relaxation are unclear. We hypothesized that increased uterine stretch during pregnancy is associated with upregulation of matrix metalloproteinases (MMPs), which in turn cause...
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